Title : Zinc as chaperone-mimicking agent for retardation of amyloid β peptide fibril formation.

Pub. Date : 2015 Apr 28

PMID : 25825723






1 Functional Relationships(s)
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1 By applying a combination of NMR relaxation dispersion and fluorescence kinetics methods we have investigated quantitatively the thermodynamic Abeta-Zn(2+) binding features as well as how Zn(2+) modulates the nucleation mechanism of the aggregation process. Zinc amyloid beta precursor protein Homo sapiens