Pub. Date : 2015 Jul
PMID : 25824027
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arsenic trioxide inhibits breast cancer cell growth via microRNA-328/hERG pathway in MCF-7 cells. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 2 | In a previous study by this group, it was shown that As2O3 induces the apoptosis of MCF-7 breast cancer cells through inhibition of the human ether-a-go-go-related gene (hERG) channel. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 3 | Further investigation using western blot analysis and reverse transcription-quantitative polymerase chain reaction revealed that As2O3 downregulated hERG expression via upregulation of miR-328 expression in MCF-7 cells. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
| 4 | In conclusion, As2O3 was observed to inhibit breast cancer cell growth, at least in part, through the miR-328/hERG pathway. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |