Title : By activating matrix metalloproteinase-7, shear stress promotes chondrosarcoma cell motility, invasion and lung colonization.

Pub. Date : 2015 Apr 20

PMID : 25823818






1 Functional Relationships(s)
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1 Specifically, shear-induced cAMP and IL-1beta activate PI3-K, ERK1/2 and p38 signaling pathways, which lead to the synthesis of MMP-7 via transactivating NF-kappaB and c-Jun in human chondrosarcoma cells. Cyclic AMP mitogen-activated protein kinase 1 Homo sapiens