Title : Vinpocetine reduces carrageenan-induced inflammatory hyperalgesia in mice by inhibiting oxidative stress, cytokine production and NF-κB activation in the paw and spinal cord.

Pub. Date : 2015

PMID : 25822523






3 Functional Relationships(s)
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1 Vinpocetine reduces carrageenan-induced inflammatory hyperalgesia in mice by inhibiting oxidative stress, cytokine production and NF-kappaB activation in the paw and spinal cord. vinpocetine nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 Both peripherally and in the spinal cord, vinpocetine also inhibited: antioxidant capacity and GSH depletion; increased superoxide anion; IL-1beta and TNF-alpha levels; and NF-kappaB activation. vinpocetine nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 As such, vinpocetine significantly reduces inflammatory pain by targeting oxidative stress, cytokine production and NF-kappaB activation at both peripheral and spinal cord levels. vinpocetine nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus