Title : Expression of hedgehog signal pathway in articular cartilage is associated with the severity of cartilage damage in rats with adjuvant-induced arthritis.

Pub. Date : 2015

PMID : 25821409






1 Functional Relationships(s)
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1 In vitro, cyclopamine effectively decreased the mRNA levels of Shh, Ptch1, Smo and Gli1, and increased the mRNA levels of COII and aggrecan in AIA chondrocytes, suggesting Hh signal inhibition might directly promote ECM production. cyclopamine sonic hedgehog signaling molecule Rattus norvegicus