Title : Organic Anion Transporter 4-Mediated Transport of Olmesartan at Basal Plasma Membrane of Human Placental Barrier.

Pub. Date : 2015 Sep

PMID : 25820021






3 Functional Relationships(s)
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Protein Name
Organism
1 Olmesartan uptake via OAT4 was concentration dependent with a Km of 20 muM, and was increased in the absence of chloride. olmesartan solute carrier family 22 member 11 Homo sapiens
2 [(3) H]Olmesartan efflux via OAT4 was also observed and was trans-stimulated by extracellular chloride and DHEAS. olmesartan solute carrier family 22 member 11 Homo sapiens
3 Efflux transport of olmesartan via OAT4 from syncytiotrophoblasts to the fetal circulation might be facilitated in the presence of an inwardly directed physiological chloride gradient and extracellular DHEAS. olmesartan solute carrier family 22 member 11 Homo sapiens