Pub. Date : 2015 May 20
PMID : 25817604
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affect renal function in patients with rheumatoid arthritis. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | BACKGROUND: This study aimed to evaluate the blood exposure of and clinical responses to tacrolimus based on genetic variants of CYP3A5 and ABCB1 in patients with rheumatoid arthritis. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | The ABCB1 3435TT group had higher dose-normalized blood concentrations of tacrolimus and 13-O-demethylate. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | ABCB1 C3435T led to a higher blood exposure of tacrolimus and its major metabolite. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | The ABCB1 genetic variant and its associated tacrolimus pharmacokinetics affected renal function in rheumatoid arthritis patients. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |