Title : Microbial-derived lithocholic acid and vitamin K2 drive the metabolic maturation of pluripotent stem cells-derived and fetal hepatocytes.

Pub. Date : 2015 Jul

PMID : 25808545






1 Functional Relationships(s)
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1 Differentiated cells produce albumin and apolipoprotein B100 at levels equivalent to primary human hepatocytes, while demonstrating an 8-fold induction of CYP450 activity in response to aryl hydrocarbon receptor (AhR) agonist omeprazole and a 10-fold induction in response to PXR agonist rifampicin. Rifampin cytochrome P450 family 4 subfamily F member 3 Homo sapiens