Pub. Date : 2015 Jul
PMID : 25806604
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of JNK pathway in spinal astrocytes contributes to acute ultra-low-dose morphine thermal hyperalgesia. | Morphine | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Morphine elevated spinal JNK1, JNK2, and c-Jun phosphorylation. | Morphine | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Pretreatment with a PKC inhibitor prevented morphine hyperalgesia and JNK and c-Jun overphosphorylation, indicating PKC is a JNK upstream modulator and illustrating the presence of a pathway involving PKC, NMDA, and JNK activated by morphine. | Morphine | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Pretreatment with a PKC inhibitor prevented morphine hyperalgesia and JNK and c-Jun overphosphorylation, indicating PKC is a JNK upstream modulator and illustrating the presence of a pathway involving PKC, NMDA, and JNK activated by morphine. | Morphine | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Pretreatment with a PKC inhibitor prevented morphine hyperalgesia and JNK and c-Jun overphosphorylation, indicating PKC is a JNK upstream modulator and illustrating the presence of a pathway involving PKC, NMDA, and JNK activated by morphine. | Morphine | mitogen-activated protein kinase 8 | Homo sapiens |
| 6 | Pretreatment with a PKC inhibitor prevented morphine hyperalgesia and JNK and c-Jun overphosphorylation, indicating PKC is a JNK upstream modulator and illustrating the presence of a pathway involving PKC, NMDA, and JNK activated by morphine. | Morphine | mitogen-activated protein kinase 8 | Homo sapiens |
| 7 | Pretreatment with a PKC inhibitor prevented morphine hyperalgesia and JNK and c-Jun overphosphorylation, indicating PKC is a JNK upstream modulator and illustrating the presence of a pathway involving PKC, NMDA, and JNK activated by morphine. | Morphine | mitogen-activated protein kinase 8 | Homo sapiens |
| 8 | These results illustrate the selective activation of an astrocyte JNK pathway after the stimulation of neuronal MOR, which contributes to ultra-low-dose morphine hyperalgesia. | Morphine | mitogen-activated protein kinase 8 | Homo sapiens |