Pub. Date : 2015 May 8
PMID : 25802332
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iron-induced Local Complement Component 3 (C3) Up-regulation via Non-canonical Transforming Growth Factor (TGF)-beta Signaling in the Retinal Pigment Epithelium. | Iron | complement C3 | Homo sapiens |
| 2 | In this study, we investigated the molecular mechanisms by which complement component 3 (C3), a central protein in the complement cascade, is up-regulated by iron in RPE cells. | Iron | complement C3 | Homo sapiens |
| 3 | In this study, we investigated the molecular mechanisms by which complement component 3 (C3), a central protein in the complement cascade, is up-regulated by iron in RPE cells. | Iron | complement C3 | Homo sapiens |
| 4 | Modulation of TGF-beta signaling, involving ERK1/2, SMAD3, and CCAAT/enhancer-binding protein-delta, is responsible for iron-induced C3 expression. | Iron | complement C3 | Homo sapiens |
| 5 | Pharmacologic inhibition of either ERK1/2 or SMAD3 phosphorylation decreased iron-induced C3 expression levels. | Iron | complement C3 | Homo sapiens |
| 6 | Knockdown of SMAD3 blocked the iron-induced up-regulation and nuclear accumulation of CCAAT/enhancer-binding protein-delta, a transcription factor that has been shown previously to bind the basic leucine zipper 1 domain in the C3 promoter. | Iron | complement C3 | Homo sapiens |
| 7 | We show herein that mutation of this domain reduced iron-induced C3 promoter activity. | Iron | complement C3 | Homo sapiens |
| 8 | In vivo studies support our in vitro finding of iron-induced C3 up-regulation. | Iron | complement C3 | Homo sapiens |
| 9 | The molecular events in the iron-C3 pathway represent therapeutic targets for AMD or other diseases exacerbated by iron-induced local complement dysregulation. | Iron | complement C3 | Homo sapiens |