Pub. Date : 2015 Apr 2
PMID : 25799988
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Notably, p53(3KR), an acetylation-defective mutant that fails to induce cell-cycle arrest, senescence and apoptosis, fully retains the ability to regulate SLC7A11 expression and induce ferroptosis upon reactive oxygen species (ROS)-induced stress. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | Notably, p53(3KR), an acetylation-defective mutant that fails to induce cell-cycle arrest, senescence and apoptosis, fully retains the ability to regulate SLC7A11 expression and induce ferroptosis upon reactive oxygen species (ROS)-induced stress. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | Our findings uncover a new mode of tumour suppression based on p53 regulation of cystine metabolism, ROS responses and ferroptosis. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |