Title : Influence of cyclic nucleotides on receptor binding, immunological activity, and microheterogeneity of human choriogonadotropin synthesized in placental tissue culture.

Pub. Date : 1985 Feb

PMID : 2579862






4 Functional Relationships(s)
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1 The efficacy of the substances to cause an increase in the hCG medium concentration was in the following order: IBMX less than control less than 8-bromo-cGMP = 8-bromo-cAMP less than cGMP + IBMX less than cAMP + IBMX. 8-Bromo Cyclic Adenosine Monophosphate hypertrichosis 2 (generalised, congenital) Homo sapiens
2 Only in the presence of 8-bromo-cAMP, 8-bromo-cGMP, and cGMP + IBMX was hCG synthesized, which differs significantly in the investigated properties from hCG of the control cultures. 8-Bromo Cyclic Adenosine Monophosphate hypertrichosis 2 (generalised, congenital) Homo sapiens
3 In the presence of both 8-bromo-cAMP and 8-bromo-cGMP, microheterogeneity of hCG in isoelectric focusing was diminished and the synthesis of more acidic hCG subpopulations was favoured. 8-Bromo Cyclic Adenosine Monophosphate hypertrichosis 2 (generalised, congenital) Homo sapiens
4 In the presence of both 8-bromo-cAMP and 8-bromo-cGMP, microheterogeneity of hCG in isoelectric focusing was diminished and the synthesis of more acidic hCG subpopulations was favoured. 8-Bromo Cyclic Adenosine Monophosphate hypertrichosis 2 (generalised, congenital) Homo sapiens