Title : Induction of UDP-glucuronosyltransferase 2B15 gene expression by the major active metabolites of tamoxifen, 4-hydroxytamoxifen and endoxifen, in breast cancer cells.

Pub. Date : 2015 Jun

PMID : 25795461






3 Functional Relationships(s)
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1 We previously reported upregulation of UGT2B15 by 17beta-estradiol in breast cancer MCF7 cells via binding of the estrogen receptor alpha (ERalpha) to an estrogen response unit (ERU) in the proximal UGT2B15 promoter. Estradiol UDP glucuronosyltransferase family 2 member B15 Homo sapiens
2 We previously reported upregulation of UGT2B15 by 17beta-estradiol in breast cancer MCF7 cells via binding of the estrogen receptor alpha (ERalpha) to an estrogen response unit (ERU) in the proximal UGT2B15 promoter. Estradiol UDP glucuronosyltransferase family 2 member B15 Homo sapiens
3 Together, these data indicate that both 17beta-estradiol and the antiestrogen 4-OHTAM upregulate UGT2B15 in MCF7 cells via the same ERalpha-signaling pathway. Estradiol UDP glucuronosyltransferase family 2 member B15 Homo sapiens