Title : Induction of UDP-glucuronosyltransferase 2B15 gene expression by the major active metabolites of tamoxifen, 4-hydroxytamoxifen and endoxifen, in breast cancer cells.

Pub. Date : 2015 Jun

PMID : 25795461






2 Functional Relationships(s)
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1 Induction of UDP-glucuronosyltransferase 2B15 gene expression by the major active metabolites of tamoxifen, 4-hydroxytamoxifen and endoxifen, in breast cancer cells. Tamoxifen UDP glucuronosyltransferase family 2 member B15 Homo sapiens
2 Furthermore, we found that, similar to 17beta-estradiol, 4-OHTAM and endoxifen (another major active TAM metabolite) elevated UGT2B15 mRNA levels, and that this stimulation was significantly abrogated by fulvestrant. Tamoxifen UDP glucuronosyltransferase family 2 member B15 Homo sapiens