Pub. Date : 2015 Jun
PMID : 25794333
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methylone has been assumed to induce hyperthermic effects through inhibition of serotonin and/or dopamine transporters (SERT and DAT, respectively). | methylone | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |
| 2 | By contrast, only a slight diminution in the hyperthermic effects of methylone was observed in DAT KO mice, whereas a slight enhancement of these effects was observed in SERT KO mice. | methylone | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |
| 3 | In contradistinction to 3,4-methylenedioxymethamphetamine, which induces its toxicity through SERT and DAT, these data indicate that DAT, but not SERT, is strongly associated with the lethal toxicity produced by methylone, which did not seem to be dependent on the hyperthermic effects of methylone. | methylone | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |
| 4 | In contradistinction to 3,4-methylenedioxymethamphetamine, which induces its toxicity through SERT and DAT, these data indicate that DAT, but not SERT, is strongly associated with the lethal toxicity produced by methylone, which did not seem to be dependent on the hyperthermic effects of methylone. | methylone | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |
| 5 | DAT is therefore a strong candidate molecule for interventions aimed at preventing acute neurotoxic and lethal effects of methylone. | methylone | solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 | Mus musculus |