Pub. Date : 2015 May
PMID : 25794161
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genetic and phenotypic variation in UGT2B17, a testosterone-metabolizing enzyme, is associated with BMI in males. | Testosterone | UDP glucuronosyltransferase family 2 member B17 | Homo sapiens |
| 2 | In humans, UDP-glucuronosyltransferase 2B17 (UGT2B17) metabolizes testosterone to a metabolite, which is readily excreted in urine. | Testosterone | UDP glucuronosyltransferase family 2 member B17 | Homo sapiens |
| 3 | In humans, UDP-glucuronosyltransferase 2B17 (UGT2B17) metabolizes testosterone to a metabolite, which is readily excreted in urine. | Testosterone | UDP glucuronosyltransferase family 2 member B17 | Homo sapiens |
| 4 | RESULTS: In Alaska Native people, UGT2B17 deletion was strongly associated with lower BMI in male individuals (P<0.001), but not in female individuals, consistent with testosterone being a male dominant steroid. | Testosterone | UDP glucuronosyltransferase family 2 member B17 | Homo sapiens |
| 5 | This is consistent with the hypothesis that reduced UGT2B17-mediated testosterone excretion results in higher testosterone levels. | Testosterone | UDP glucuronosyltransferase family 2 member B17 | Homo sapiens |
| 6 | This is consistent with the hypothesis that reduced UGT2B17-mediated testosterone excretion results in higher testosterone levels. | Testosterone | UDP glucuronosyltransferase family 2 member B17 | Homo sapiens |