Pub. Date : 2015
PMID : 25793995
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we demonstrate that high glucose significantly downregulates both the mRNA and protein levels of SIRT1 and upregulates the mRNA level and the release of two pro-inflammatory cytokines, IL-1beta and TNF-alpha, in RAW264.7 macrophages. | Glucose | interleukin 1 beta | Mus musculus |
| 2 | However, when the function of SIRT1 is inhibited by EX527 or its expression is suppressed by RNAi, the upregulated level and release of IL-1beta and TNF-alpha by high glucose are further increased. | Glucose | interleukin 1 beta | Mus musculus |