Title : Cardiac dysfunction caused by purified human C3a anaphylatoxin.

Pub. Date : 1985 Feb

PMID : 2579381






3 Functional Relationships(s)
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1 As a function of dose, C3a caused tachycardia, impairment of atrioventricular conduction, left ventricular contractile failure, coronary vasoconstriction, and histamine release. Histamine complement C3 Homo sapiens
2 The magnitude of C3a-induced tachycardia correlated with the amount of endogenous cardiac histamine released into the coronary effluent. Histamine complement C3 Homo sapiens
3 This suggests that histamine, leukotrienes, and vasoactive prostanoates may mediate the various cardiac effects of C3a. Histamine complement C3 Homo sapiens