Pub. Date : 2015
PMID : 25793262
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dimethyl fumarate and monoethyl fumarate exhibit differential effects on KEAP1, NRF2 activation, and glutathione depletion in vitro. | Dimethyl Fumarate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Previous studies have provided insight into the pharmacologic properties of DMF, including modulation of kelch-like ECH-associated protein 1 (KEAP1), activation of the nuclear factor (erythroid-derived 2)-like 2 (NRF2) pathway, and glutathione (GSH) modulation; however, those of MEF remain largely unexplored. | Dimethyl Fumarate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Consistent with KEAP1 cysteine modification, DMF treatment resulted in nuclear translocation of NRF2 and a robust transcriptional response in treated cells, as did MEF; however, the responses to MEF were of a lower magnitude or distinct compared to DMF. | Dimethyl Fumarate | NFE2 like bZIP transcription factor 2 | Homo sapiens |