Pub. Date : 2015 Jul 1
PMID : 25791922
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. | Glutamic Acid | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Glutamate stimulation induced reactive oxygen species (ROS), endoplasmic reticulum stress (ER stress) and TXNIP/NLRP3 inflammasome activation, leading to damage in the hippocampus. | Glutamic Acid | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Together, these results showed that curcumin attenuated glutamate neurotoxicity by inhibiting ER stress-associated TXNIP/NLRP3 inflammasome activation via the regulation of AMPK, and thereby protected the hippocampus from ischemic insult. | Glutamic Acid | NLR family pyrin domain containing 3 | Homo sapiens |