Pub. Date : 2015 May 15
PMID : 25791921
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TG-interacting factor transcriptionally induced by AKT/FOXO3A is a negative regulator that antagonizes arsenic trioxide-induced cancer cell apoptosis. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Furthermore, blockage of the AKT pathway enhanced ATO-induced CDKN1A expression and resultant apoptosis in cancer cells, but overexpression of AKT1 inhibited CDKN1A expression. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Therefore, we suggest that TGIF is transcriptionally regulated by the c-Src/EGFR/AKT pathway, which plays a role as a negative regulator in antagonizing ATO-induced CDKN1A expression and resultant apoptosis. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |