Pub. Date : 2015 May 1
PMID : 25791477
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anticancer drug bortezomib increases interleukin-8 expression in human monocytes. | Bortezomib | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | Since monocytes and macrophages are major producers of IL-8, the goal of this study was to test the hypothesis that BZ increases the IL-8 expression in human monocytes and macrophages. | Bortezomib | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | Since monocytes and macrophages are major producers of IL-8, the goal of this study was to test the hypothesis that BZ increases the IL-8 expression in human monocytes and macrophages. | Bortezomib | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | Here, we show that BZ dramatically increases the IL-8 expression in lipopolysaccharide (LPS)-stimulated U937 macrophages as well as in unstimulated U937 monocytes and peripheral blood mononuclear cells, while it inhibits expression of IL-6, IL-1 and tumor necrosis factor-alpha. | Bortezomib | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | In addition, our results show that the underlying mechanisms involve p38 mitogen-activated protein kinase, which is required for the BZ-induced IL-8 expression. | Bortezomib | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 6 | Together, these data suggest that the BZ-increased IL-8 expression in monocytes and macrophages may represent one of the mechanisms responsible for the BZ resistance and indicate that targeting the p38-mediated IL-8 expression could enhance the BZ effectiveness in cancer treatment. | Bortezomib | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 7 | Together, these data suggest that the BZ-increased IL-8 expression in monocytes and macrophages may represent one of the mechanisms responsible for the BZ resistance and indicate that targeting the p38-mediated IL-8 expression could enhance the BZ effectiveness in cancer treatment. | Bortezomib | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 8 | Together, these data suggest that the BZ-increased IL-8 expression in monocytes and macrophages may represent one of the mechanisms responsible for the BZ resistance and indicate that targeting the p38-mediated IL-8 expression could enhance the BZ effectiveness in cancer treatment. | Bortezomib | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 9 | Together, these data suggest that the BZ-increased IL-8 expression in monocytes and macrophages may represent one of the mechanisms responsible for the BZ resistance and indicate that targeting the p38-mediated IL-8 expression could enhance the BZ effectiveness in cancer treatment. | Bortezomib | C-X-C motif chemokine ligand 8 | Homo sapiens |