Title : Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated.

Pub. Date : 2015

PMID : 25790475






4 Functional Relationships(s)
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Protein Name
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1 Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated. polyglutamine ataxin 2 Mus musculus
2 The single RING finger type E3 ubiquitin-protein ligase PARK2 is mutated in a Parkinson"s disease (PD) variant and was found to interact with ATXN2, a protein where polyglutamine expansions cause Spinocerebellar ataxia type 2 (SCA2) or increase the risk for Levodopa-responsive PD and for the motor neuron disease Amyotrophic lateral sclerosis (ALS). polyglutamine ataxin 2 Mus musculus
3 The single RING finger type E3 ubiquitin-protein ligase PARK2 is mutated in a Parkinson"s disease (PD) variant and was found to interact with ATXN2, a protein where polyglutamine expansions cause Spinocerebellar ataxia type 2 (SCA2) or increase the risk for Levodopa-responsive PD and for the motor neuron disease Amyotrophic lateral sclerosis (ALS). polyglutamine ataxin 2 Mus musculus
4 The single RING finger type E3 ubiquitin-protein ligase PARK2 is mutated in a Parkinson"s disease (PD) variant and was found to interact with ATXN2, a protein where polyglutamine expansions cause Spinocerebellar ataxia type 2 (SCA2) or increase the risk for Levodopa-responsive PD and for the motor neuron disease Amyotrophic lateral sclerosis (ALS). polyglutamine ataxin 2 Mus musculus