Pub. Date : 2015
PMID : 25790475
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Both ubiquitin ligases FBXW8 and PARK2 are sequestrated into insolubility by ATXN2 PolyQ expansions, but only FBXW8 expression is dysregulated. | polyglutamine | ataxin 2 | Mus musculus |
2 | The single RING finger type E3 ubiquitin-protein ligase PARK2 is mutated in a Parkinson"s disease (PD) variant and was found to interact with ATXN2, a protein where polyglutamine expansions cause Spinocerebellar ataxia type 2 (SCA2) or increase the risk for Levodopa-responsive PD and for the motor neuron disease Amyotrophic lateral sclerosis (ALS). | polyglutamine | ataxin 2 | Mus musculus |
3 | The single RING finger type E3 ubiquitin-protein ligase PARK2 is mutated in a Parkinson"s disease (PD) variant and was found to interact with ATXN2, a protein where polyglutamine expansions cause Spinocerebellar ataxia type 2 (SCA2) or increase the risk for Levodopa-responsive PD and for the motor neuron disease Amyotrophic lateral sclerosis (ALS). | polyglutamine | ataxin 2 | Mus musculus |
4 | The single RING finger type E3 ubiquitin-protein ligase PARK2 is mutated in a Parkinson"s disease (PD) variant and was found to interact with ATXN2, a protein where polyglutamine expansions cause Spinocerebellar ataxia type 2 (SCA2) or increase the risk for Levodopa-responsive PD and for the motor neuron disease Amyotrophic lateral sclerosis (ALS). | polyglutamine | ataxin 2 | Mus musculus |