Pub. Date : 2015 Apr
PMID : 25789066
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A let-7b binding site SNP in the 3"-UTR of the Bcl-xL gene enhances resistance to 5-fluorouracil and doxorubicin in breast cancer cells. | Doxorubicin | BCL2 like 1 | Homo sapiens |
| 2 | The data indicated that let-7b negatively regulates the expression of Bcl-xL and appears to sensitize MCF-7 cells to the chemotherapeutic agents 5-fluorouracil (5-FU) and doxorubicin. | Doxorubicin | BCL2 like 1 | Homo sapiens |
| 3 | Furthermore, the SNP rs3208684 A>C was demonstrated to enhance Bcl-xL protein expression by disrupting the binding of let-7b to the 3"-UTR of Bcl-xL and, in MCF-7 cells, overexpression of let-7b in the presence of a mutant Bcl-xL 3"-UTR (C allele) significantly increased 5-FU and doxorubicin resistance. | Doxorubicin | BCL2 like 1 | Homo sapiens |
| 4 | Thus, the results of the present study demonstrate that the SNP rs3208684 A>C may upregulate Bcl-xL protein expression and enhance the resistance of the MCF-7 cells to 5-FU and doxorubicin by decreasing the binding of let-7b to the 3"-UTR of Bcl-xL. | Doxorubicin | BCL2 like 1 | Homo sapiens |
| 5 | Thus, the results of the present study demonstrate that the SNP rs3208684 A>C may upregulate Bcl-xL protein expression and enhance the resistance of the MCF-7 cells to 5-FU and doxorubicin by decreasing the binding of let-7b to the 3"-UTR of Bcl-xL. | Doxorubicin | BCL2 like 1 | Homo sapiens |