Pub. Date : 2015 Oct
PMID : 25787859
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors. | imidazo(1,2-a)pyridine | dipeptidyl peptidase 4 | Homo sapiens |
| 2 | A new series of DPP-4 inhibitors with imidazo[1,2-a]pyridine scaffold were designed by exploiting scaffold hopping strategy and docking study. | imidazo(1,2-a)pyridine | dipeptidyl peptidase 4 | Homo sapiens |
| 3 | Further, molecular docking revealed that compound 5d could retain key binding features of DPP-4 with the pyridine moiety of imidazo[1,2-a]pyridine ring providing an additional pi-pi interaction with Phe357 of DPP-4. | imidazo(1,2-a)pyridine | dipeptidyl peptidase 4 | Homo sapiens |