Title : Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells.

Pub. Date : 2015 Jun

PMID : 25787249






3 Functional Relationships(s)
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1 To examine whether the long non-coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) is altered in the endothelial cells in response to glucose and the significance of such alteration. Glucose metastasis associated lung adenocarcinoma transcript 1 Homo sapiens
2 We found an increase in MALAT1 expression peaking after 12 hrs of incubation in high glucose. Glucose metastasis associated lung adenocarcinoma transcript 1 Homo sapiens
3 Results of this study indicate that LncRNA MALAT1 regulates glucose-induced up-regulation of inflammatory mediators IL-6 and TNF-alpha through activation of SAA3. Glucose metastasis associated lung adenocarcinoma transcript 1 Homo sapiens