Title : Attenuation of LPS-induced cyclooxygenase-2 and inducible NO synthase expression by lysophosphatidic acid in macrophages.

Pub. Date : 2015 Aug

PMID : 25783839






2 Functional Relationships(s)
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1 LPA was able to diminish LPS-induced phosphorylation of p38 and Akt, as well as NF-kappaB p65 nuclear translocation. lysophosphatidic acid AKT serine/threonine kinase 1 Homo sapiens
2 Our findings demonstrate a clear anti-inflammatory role of LPA acting via Galpha(i) in LPS-mediated inflammatory response in macrophages, owing, at least in part, to its suppressive effect on LPS-induced activation of p38, Akt and NF-kappaB. lysophosphatidic acid AKT serine/threonine kinase 1 Homo sapiens