Title : Curcumin improves the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cells via the NF-κB-p53-caspase-3 pathway.

Pub. Date : 2015 Apr

PMID : 25780454






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Curcumin improves the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cells via the NF-kappaB-p53-caspase-3 pathway. Curcumin tumor protein p53 Homo sapiens
2 The expression levels of p53 protein and cleaved caspase-3 were increased significantly in the curcumin plus paclitaxel-treated HeLa and CaSki cells compared with those in the cells treated with paclitaxel alone (P<0.01). Curcumin tumor protein p53 Homo sapiens
3 This suggests that the combined effect of curcumin and paclitaxel was associated with the NF-kappaB-p53-caspase-3 pathway. Curcumin tumor protein p53 Homo sapiens
4 In conclusion, curcumin has the ability to improve the paclitaxel-induced apoptosis of HPV-positive human cervical cancer cell lines via the NF-kappaB-p53-caspase-3 pathway. Curcumin tumor protein p53 Homo sapiens