Title : Enalapril stimulates collagen biosynthesis through prolidase-dependent mechanism in cultured fibroblasts.

Pub. Date : 2015 Jun

PMID : 25772062






1 Functional Relationships(s)
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1 Enalapril- and enalaprilat-dependent increase of collagen biosynthesis in fibroblasts results from increase of prolidase activity and expression, which may undergo through activation of alpha2beta1 integrin and IGF-IR signaling as well as upregulation of TGF-beta1 and NF-kappaB p65, the inhibitor of collagen gene expression. Enalaprilat peptidase D Homo sapiens