Title : Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53.

Pub. Date : 2015 May 5

PMID : 25770930






1 Functional Relationships(s)
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1 Combination of chrysin and cisplatin increased the phosphorylation and accumulation of p53 through activating ERK1/2 in Hep G2 cells, which led to the overexpression of the pro-apoptotic proteins Bax and DR5 and the inhibition of the anti-apoptotic protein Bcl-2. Cisplatin mitogen-activated protein kinase 3 Homo sapiens