Title : Targeting nodal in conjunction with dacarbazine induces synergistic anticancer effects in metastatic melanoma.

Pub. Date : 2015 Apr

PMID : 25767211






2 Functional Relationships(s)
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1 In this study, we sought to determine how Nodal-positive human melanoma cells respond to DTIC treatment and to ascertain whether targeting Nodal in combination with DTIC would be more effective than monotherapy. Dacarbazine nodal growth differentiation factor Homo sapiens
2 Rather than reducing Nodal expression, DTIC increased the size of the Nodal-positive subpopulation, an observation coincident with increased cellular invasion. Dacarbazine nodal growth differentiation factor Homo sapiens