Pub. Date : 2015 Mar 12
PMID : 25766317
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reactive oxygen species and p21Waf1/Cip1 are both essential for p53-mediated senescence of head and neck cancer cells. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | DNA-damaging reactive oxygen species (ROS) are a by-product of ionizing radiation that lead to the activation of p53, transcription of p21(cip1/waf1) and, in the case of wild-type TP53 HNSCC cells, cause senescence. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | DNA-damaging reactive oxygen species (ROS) are a by-product of ionizing radiation that lead to the activation of p53, transcription of p21(cip1/waf1) and, in the case of wild-type TP53 HNSCC cells, cause senescence. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 4 | DNA-damaging reactive oxygen species (ROS) are a by-product of ionizing radiation that lead to the activation of p53, transcription of p21(cip1/waf1) and, in the case of wild-type TP53 HNSCC cells, cause senescence. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 5 | DNA-damaging reactive oxygen species (ROS) are a by-product of ionizing radiation that lead to the activation of p53, transcription of p21(cip1/waf1) and, in the case of wild-type TP53 HNSCC cells, cause senescence. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 6 | For the first time, we show that persistent exposure to low levels of the ROS, hydrogen peroxide, leads to the long-term expression of p21 in HNSCC cells with a partially functional TP53, resulting in senescence. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 7 | We conclude that the level of ROS is crucial in initiating p53"s transcription of p21 leading to senescence. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 8 | It is p21"s ability to sustain elevated levels of ROS, in turn, that allows for a long-term oxidative stress, and ensures an active p53-p21-ROS signaling loop. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 9 | It is p21"s ability to sustain elevated levels of ROS, in turn, that allows for a long-term oxidative stress, and ensures an active p53-p21-ROS signaling loop. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |