Title : Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β.

Pub. Date : 2015

PMID : 25764208






4 Functional Relationships(s)
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1 Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1alpha and IL-1beta. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid interleukin 1 alpha Homo sapiens
2 Here, we describe the generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig) of the IgG1/k subtype that specifically and potently neutralizes IL-1alpha and IL-1beta. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid interleukin 1 alpha Homo sapiens
3 ABT-981 specifically binds to IL-1alpha and IL-1beta, and is physically capable of binding 2 human IL-1alpha and 2 human IL-1beta molecules simultaneously. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid interleukin 1 alpha Homo sapiens
4 ABT-981 specifically binds to IL-1alpha and IL-1beta, and is physically capable of binding 2 human IL-1alpha and 2 human IL-1beta molecules simultaneously. 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid interleukin 1 alpha Homo sapiens