Title : Compartmentalized accumulation of cAMP near complexes of multidrug resistance protein 4 (MRP4) and cystic fibrosis transmembrane conductance regulator (CFTR) contributes to drug-induced diarrhea.

Pub. Date : 2015 May 1

PMID : 25762723






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Several drugs are either substrates or inhibitors of multidrug resistance protein 4 (MRP4), such as the anti-colon cancer drug irinotecan and an anti-retroviral used to treat HIV infection, 3"-azido-3"-deoxythymidine (AZT). Zidovudine ATP binding cassette subfamily C member 4 Homo sapiens
2 Several drugs are either substrates or inhibitors of multidrug resistance protein 4 (MRP4), such as the anti-colon cancer drug irinotecan and an anti-retroviral used to treat HIV infection, 3"-azido-3"-deoxythymidine (AZT). Zidovudine ATP binding cassette subfamily C member 4 Homo sapiens
3 Several drugs are either substrates or inhibitors of multidrug resistance protein 4 (MRP4), such as the anti-colon cancer drug irinotecan and an anti-retroviral used to treat HIV infection, 3"-azido-3"-deoxythymidine (AZT). Zidovudine ATP binding cassette subfamily C member 4 Homo sapiens
4 Several drugs are either substrates or inhibitors of multidrug resistance protein 4 (MRP4), such as the anti-colon cancer drug irinotecan and an anti-retroviral used to treat HIV infection, 3"-azido-3"-deoxythymidine (AZT). Zidovudine ATP binding cassette subfamily C member 4 Homo sapiens
5 Importantly, HIV patients on AZT treatment demonstrate augmented MRP4-CFTR complex formation in the colon, which defines a novel paradigm of drug-induced diarrhea. Zidovudine ATP binding cassette subfamily C member 4 Homo sapiens