Pub. Date : 2015
PMID : 25759055
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The findings suggested that a combination of multiple transporters involving organic anion transporting polypeptide (OATP) 2B1, P-glycoprotein (P-gp), and multidrug resistance-associated protein 2 (MRP2) react to stereoselective fexofenadine exposure. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | The findings suggested that a combination of multiple transporters involving organic anion transporting polypeptide (OATP) 2B1, P-glycoprotein (P-gp), and multidrug resistance-associated protein 2 (MRP2) react to stereoselective fexofenadine exposure. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Coadministration of P-gp inducer/inhibitors significantly altered the pharmacokinetics of fexofenadine enantiomers. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Taken together, these studies indicated that multiple transporters including P-gp, OATPs, and MRP2 play important roles in fexofenadine enantiomer pharmacokinetics. | fexofenadine | ATP binding cassette subfamily B member 1 | Homo sapiens |