Pub. Date : 2015 Jun
PMID : 25757564
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin E2 transactivates the colony-stimulating factor-1 receptor and synergizes with colony-stimulating factor-1 in the induction of macrophage migration via the mitogen-activated protein kinase ERK1/2. | Dinoprostone | mitogen-activated protein kinase 3 | Mus musculus |
| 2 | CSF-1R inhibition reduced PGE2-elicited ERK1/2 phosphorylation and macrophage migration, indicating that CSF-1R plays a role in PGE2-mediated immunoregulation. | Dinoprostone | mitogen-activated protein kinase 3 | Mus musculus |
| 3 | CSF-1R inhibition reduced PGE2-elicited ERK1/2 phosphorylation and macrophage migration, indicating that CSF-1R plays a role in PGE2-mediated immunoregulation. | Dinoprostone | mitogen-activated protein kinase 3 | Mus musculus |
| 4 | Furthermore, PGE2 synergized with CSF-1 in inducing ERK1/2 phosphorylation and macrophage migration. | Dinoprostone | mitogen-activated protein kinase 3 | Mus musculus |
| 5 | ERK1/2 inhibition completely blocked migration induced by the combination CSF-1/PGE2. | Dinoprostone | mitogen-activated protein kinase 3 | Mus musculus |
| 6 | These results indicated that PGE2 transactivates CSF-1R and synergizes with its signaling at ERK1/2 level in promoting macrophage migration. | Dinoprostone | mitogen-activated protein kinase 3 | Mus musculus |