Title : More effective DPP4 inhibitors as antidiabetics based on sitagliptin applied QSAR and clinical methods.

Pub. Date : 2014

PMID : 25756669






1 Functional Relationships(s)
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1 We establish that the physicochemical parameters critical for DPP4 inhibitory activity are: hydrophobicity described by the logarithm of the octanol/water partition coefficient, counts of rotatable bonds, hydrogen bond donor and acceptor atoms, and topological polar surface area. Octanols dipeptidyl peptidase 4 Homo sapiens