Title : EGFR signaling defines Mcl⁻1 survival dependency in neuroblastoma.

Pub. Date : 2015

PMID : 25756510






1 Functional Relationships(s)
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Compound Name
Protein Name
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1 Mechanistically treatment of NBs with small molecule inhibitors of EGFR (erlotinib, cetuximab) and ERK (U0126) increases Noxa expression and dephosphorylates Bim to promote Bim binding to Bcl(-)2. U 0126 BCL2 apoptosis regulator Homo sapiens