Title : Prevalence of UGT1A6 polymorphisms in children with epilepsy on valproate monotherapy.

Pub. Date : 2015 Jan-Feb

PMID : 25751467






5 Functional Relationships(s)
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1 Prevalence of UGT1A6 polymorphisms in children with epilepsy on valproate monotherapy. Valproic Acid UDP glucuronosyltransferase family 1 member A6 Homo sapiens
2 AIM: This study was aimed to analyze the genetic polymorphisms of UGT1A6 in Indian children with epilepsy and their potential influence on the pharmacokinetics of valproate. Valproic Acid UDP glucuronosyltransferase family 1 member A6 Homo sapiens
3 The steady-state plasma concentrations of valproate were measured by High Performance Liquid Chromatography (HPLC) and associated with UGT1A6 polymorphisms. Valproic Acid UDP glucuronosyltransferase family 1 member A6 Homo sapiens
4 The association between valproate doses or standardized serum valproate concentration and the various UGT1A6 genotypes could not be studied reliably in this small study population. Valproic Acid UDP glucuronosyltransferase family 1 member A6 Homo sapiens
5 The association between valproate doses or standardized serum valproate concentration and the various UGT1A6 genotypes could not be studied reliably in this small study population. Valproic Acid UDP glucuronosyltransferase family 1 member A6 Homo sapiens