Title : Paeoniflorin diminishes ConA-induced IL-8 production in primary human hepatic sinusoidal endothelial cells in the involvement of ERK1/2 and Akt phosphorylation.

Pub. Date : 2015 May

PMID : 25748730






1 Functional Relationships(s)
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1 Combining paeoniflorin with U0126 or LY294002 at low doses showed supra-additive inhibition of not only phospho-ERK1/2 and phospho-Akt by 46.4% and 35.0%, but also IL-8 release by 42.4% and 36.1% and IL-8 mRNA expression by 43.5% and 31.8%, respectively. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one mitogen-activated protein kinase 3 Homo sapiens