Pub. Date : 2014 Nov-Dec
PMID : 25745771
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Influence of inositol hexaphosphate on the expression of selected proliferation markers in IL-1beta-stimulated intestinal epithelial cells. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 2 | The aim of the present study was to examine the influence of IP6, a naturally occurring phytochem- ical, on the expression of genes coding for proliferation markers, i.e., cyclin D1 (CCND1) and histone H3 in IL-1beta-stimulated intestinal cancer cell line Caco-2. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 3 | Quantification of genes expression was carried out using real time RT-QPCR technique in Caco-2 cells after treatment with IL-1beta, 1 and 2.5 mM of IP6 for 3, 6 and 12 h. In separate cultures, cells were incubated with IL-1beta for the indicated times. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 4 | IP6 had no influence on IL-1beta-stimulated CCND1 expression for 3 and 6 h. After 12 h, statistically significant decrease in CCND1 mRNA was observed in cells exposed to IL-1beta and IP6 (1 and 2.5 mM) in relation to cells treated with IL-1beta only. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 5 | IP6 had no influence on IL-1beta-stimulated CCND1 expression for 3 and 6 h. After 12 h, statistically significant decrease in CCND1 mRNA was observed in cells exposed to IL-1beta and IP6 (1 and 2.5 mM) in relation to cells treated with IL-1beta only. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 6 | The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 7 | The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 8 | The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 9 | The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 10 | The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 11 | The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 12 | The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 13 | The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 14 | The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. | Phytic Acid | interleukin 1 beta | Homo sapiens |
| 15 | The levels of H3 mRNA in IL-1beta-stimulated cells and cells treated with IL-1beta and IP6 revealed no statistically significant differences after 3 h. IP6 at 1 and 2.5 mM enhanced IL1beta-stimulated transcription of H3 gene after 6 h. Subsequently (12 h), the combination of IP6 and IL-1beta decreased H3 mRNA level compared to IL1beta-treated cells. | Phytic Acid | interleukin 1 beta | Homo sapiens |