Pub. Date : 2015
PMID : 25744459
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to characterize the kinetics of metabolite formation of the phosphodiesterase type-5 (PDE5) inhibitors sildenafil and tadalafil by CYP3A4, CYP3A5, and CYP3A7 isoforms. | Sildenafil Citrate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | The formations of N-desmethyl sildenafil and desmethylene tadalafil were examined using CYP3A supersomes co-expressing human P450 oxidoreductase and cytochrome b5. | Sildenafil Citrate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Both sildenafil N-demethylation and tadalafil demethylenation were catalyzed by CYP3A4, CYP3A5, and to a lesser extent by CYP3A7. | Sildenafil Citrate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The intrinsic clearance (CLint) values of reactions 1 and 2 for sildenafil N-demethylation were 0.733 and 0.033 microL/min/pmol P450 for CYP3A4, 0.788 and 0.019 microL/min/pmol P450 for CYP3A5, and 0.079 and 0.004 microL/min/pmol P450 for CYP3A7, respectively. | Sildenafil Citrate | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |