Title : Metformin and salicylate synergistically activate liver AMPK, inhibit lipogenesis and improve insulin sensitivity.

Pub. Date : 2015 May 15

PMID : 25742316






1 Functional Relationships(s)
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1 Metformin and salicylate both increase AMP-activated protein kinase (AMPK) activity but by distinct mechanisms, with metformin altering cellular adenylate charge (increasing AMP) and salicylate interacting directly at the AMPK beta1 drug-binding site. Adenosine Monophosphate protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens