Pub. Date : 2015 May
PMID : 25738706
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of the present study was to demonstrate that ribavirin, a known inhibitor of eIF4E and inosine 5"-phosphate dehydrogenase (IMPDH), also inhibits histone methyltransferase zeste homolog 2 (EZH2). | Ribavirin | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |
| 2 | Ribavirin decreased EZH2 expression, inhibited histone methyltransferase activity and decreased H3K27 trimethylation. | Ribavirin | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |
| 3 | Ribavirin induced variable growth inhibition in a number of cell lines and downregulation of the targets, EZH2, eIF4E and IMPDH1 and 2 by siRNA led to comparable growth inhibition while no significant further reduction in viability was observed when siRNA transfected cells were treated with ribavirin. | Ribavirin | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |
| 4 | Ribavirin induced variable growth inhibition in a number of cell lines and downregulation of the targets, EZH2, eIF4E and IMPDH1 and 2 by siRNA led to comparable growth inhibition while no significant further reduction in viability was observed when siRNA transfected cells were treated with ribavirin. | Ribavirin | enhancer of zeste 2 polycomb repressive complex 2 subunit | Homo sapiens |