Title : Lithium chloride induces mesenchymal‑to‑epithelial reverting transition in primary colon cancer cell cultures.

Pub. Date : 2015 May

PMID : 25738332






4 Functional Relationships(s)
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1 Following differentiation with the glycogen synthase kinase 3beta (GSK3beta) inhibitor LiCl, the cells began to express E-cadherin and, at once, Twist1 and Snail expression was strongly downregulated, suggesting a MET-reverting process. Lithium Chloride glycogen synthase kinase 3 beta Homo sapiens
2 Following differentiation with the glycogen synthase kinase 3beta (GSK3beta) inhibitor LiCl, the cells began to express E-cadherin and, at once, Twist1 and Snail expression was strongly downregulated, suggesting a MET-reverting process. Lithium Chloride glycogen synthase kinase 3 beta Homo sapiens
3 Our observation indicates that LiCl, a GSK3beta inhibitor, induces MET in vitro, suggesting that LiCl and GSK3beta could represent, respectively, interesting drug, and target for CRC therapy. Lithium Chloride glycogen synthase kinase 3 beta Homo sapiens
4 Our observation indicates that LiCl, a GSK3beta inhibitor, induces MET in vitro, suggesting that LiCl and GSK3beta could represent, respectively, interesting drug, and target for CRC therapy. Lithium Chloride glycogen synthase kinase 3 beta Homo sapiens