Pub. Date : 2015 Jul
PMID : 25738264
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Testosterone enhances lipopolysaccharide-induced interleukin-6 and macrophage chemotactic protein-1 expression by activating the extracellular signal-regulated kinase 1/2/nuclear factor-kappaB signalling pathways in 3T3-L1 adipocytes. | Testosterone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | The effects of testosterone on the expression of proinflammatory mediators, nuclear factor-kappaB (NF-kappaB), and extracellular signal-regulated kinase 1/2 (ERK1/2) signalling pathways were investigated using an enzyme-linked immunosorbent assay, reverse transcriptase-polymerase chain reaction, western blot analysis and an electrophoresis mobility shift assay. | Testosterone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Testosterone induces the phosphorylation of ERK1/2 and NF-kappaB. | Testosterone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | The effect of testosterone on the expression of IL-6 and MCP-1 is inhibited by PD98059 , an ERK1/2 inhibitor, and PDTC, an NF-kappaB inhibitor. | Testosterone | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | The results indicate that testosterone enhances LPS-induced IL-6 and MCP-1 expression by activating the ERK1/2/NF-kappaB signalling pathways in 3T3-L1 adipocytes. | Testosterone | nuclear factor kappa B subunit 1 | Homo sapiens |