Title : Differential thiol oxidation of the signaling proteins Akt, PTEN or PP2A determines whether Akt phosphorylation is enhanced or inhibited by oxidative stress in C2C12 myotubes derived from skeletal muscle.

Pub. Date : 2015 May

PMID : 25737250






1 Functional Relationships(s)
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1 ROS, such as hydrogen peroxide, have the potential to affect signal transduction pathways such as the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3 K)/Akt pathway that regulates protein synthesis. Phosphatidylinositol 4,5-Diphosphate thymoma viral proto-oncogene 1 Mus musculus