Title : A comparison of the cholinergic activity of selected H2-antagonists and sulfoxide metabolites.

Pub. Date : 1989 Aug

PMID : 2573049






2 Functional Relationships(s)
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1 These results do not correlate with the in vitro data, where ORF-17578 and ranitidine were the most potent entities with respect to acetylcholinesterase inhibition (approximately 1-2 X 10(-6) M), followed by nizatidine greater than cimetidine greater than famotidine. Ranitidine acetylcholinesterase Mus musculus
2 The sulfoxide metabolites of ranitidine and cimetidine were approximately one-tenth as potent as their parent compounds with respect to inhibition of acetylcholinesterase. Ranitidine acetylcholinesterase Mus musculus