Title : Electron transfer by human wild-type and A287P mutant P450 oxidoreductase assessed by transient kinetics: functional basis of P450 oxidoreductase deficiency.

Pub. Date : 2015 May 15

PMID : 25728647






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cytochrome P450 oxidoreductase (POR) is a 2-flavin protein that transfers electrons from NADPH via its FAD and FMN moieties to all microsomal cytochrome P450 enzymes, including steroidogenic and drug-metabolizing P450s. NADP cytochrome p450 oxidoreductase Homo sapiens
2 Cytochrome P450 oxidoreductase (POR) is a 2-flavin protein that transfers electrons from NADPH via its FAD and FMN moieties to all microsomal cytochrome P450 enzymes, including steroidogenic and drug-metabolizing P450s. NADP cytochrome p450 oxidoreductase Homo sapiens
3 Transient kinetic dissection of the reaction of POR with NADPH and the reduction in cytochrome c by POR using stopped-flow techniques revealed defects in individual electron transfer steps mediated by A287P. NADP cytochrome p450 oxidoreductase Homo sapiens