Title : Modulation of the expression of a multidrug resistance gene (mdr-1/P-glycoprotein) by differentiating agents.

Pub. Date : 1989 Oct 25

PMID : 2572588






1 Functional Relationships(s)
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1 The levels of P-glycoprotein returned to normal with a half-life of about 24 h. In spite of a 20-25-fold increase in the level of mdr-1/Pgp mRNA and P-glycoprotein, the SW-620 cell line did not demonstrate increased resistance to doxorubicin and vinblastine or decreased accumulation of vinblastine. Doxorubicin ATP binding cassette subfamily B member 1 Homo sapiens